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If you jack up the concentration high enough almost anything can inhibit protease in vitro, but that’s not how IVM works, at physiol concentrations it affects glutamate-gated Cl channels. Paxlovid works at 3.11nM, IVM at 21uM. 6-12mg IVM gets you ~26nM. Assuming linearity, you need ~6,000-12,000mg IVM to get ~21uM. Thats over the LD50 of 15mg/kg (avg wt), which is to say the least a TON of Ivermectin.
Thank you for the math! the dose of ivermectin - wonder if any trials looked/looking into the maximum effective but safe dose in vivo or in silico.
Another key is timing. Too late to treat when the patient is hospitalized. Then it is just extraordinary life saving treatments and prayers.
Another example of the importance of dose and an early treatments
- is of one group of doctors -non-mainstream- in Russia treat Covid with blood thinners mostly; only DOACs, double the dose- they say the recommended dose is not working at all.
The key for them- early treatments- preferably at day one of the beginning of the symptoms- not waiting to start treatments at hospitalization. Their average is 6 days from the beginning of the infection counting backwards after the beginning of symptoms
No antivirals of any kind ( they convinced that very few work against the viruses in general) and they do not recommend antibiotics unless specifically indicated for a particular patient in a particular case.
They add steroids only if the DOACs did not produce the reduction of the fever in 3 days. Steroids - just a few days, no weaning - fast and furious.
Their approach makes sense- as it looks like Covid is a circulatory disease first and foremost.
They claim that they only have very few hospitalized and a very tiny fraction of dying, the ones who started the treatments late.
As they are paid privately- by willing patients- they only treated a few thousands by now.
All healthcare is free in Russia to all, but a few people get those DOACs early - when they don’t even want to go to the doctors yet - until seriously ill
Last edited by L00k4ward; 11-22-2021 at 10:19 AM..
Thank you - but it is an old information for Remdesivir - before WHO said that it is not recommended- not that I trust WHO explicitly- another organization of politicized “health” regulations.
Still not clear if Japan uses it 18 months later
It's not old information. It says it was last updated on November 2021. Japan still recommends it.
Thank you for math! the dose of ivermectin - wonder if any trials looked in the maximum effective but safe dose.
Another key is timing. Too late to treat when the patient is hospitalized.
Another example of the importance of dose and an early treatments
- is of one group of doctors -non-mainstream- in Russia treat Covid with blood thinners mostly; only DOACs, double the dose- they say the recommended dose is not working at all.
The key for them- early treatments- preferably at day one of beginning of the symptoms- not waiting to start treatments at hospitalization. Their average is 6 days from the beginning of the infection counting backwards after the beginning of symptoms
No antivirals of any kind and they do not recommend antibiotics unless specifically indicated for a particular patient in a particular case.
They add steroids only if the DOACs did not produce the reduction of the fever in 3 days.
Their approach makes sense- as it looks like Covid is a circulatory disease first and foremost.
They claim that they only have very few hospitalized and a very tiny fraction of dying, the ones who started the treatments late.
As they are paid privately- by willing patients- they only treated a few thousands.
All healthcare is free in Russia to all, a few people get those DOACs early - when they don’t even go to the doctors yet - until seriously ill
Quote:
Ivermectin has a wide therapeutic index and previous studies have shown doses up to 2000 mcg/kg
Thank you - but it is an old information for Remdesivir - before WHO said that it is not recommended- not that I trust WHO explicitly- another organization of politicized “health” regulations.
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The plot thickens, I wonder if they sought legal advice before making this decision, then lied about it in court.. - link, link2
"Sentara cannot be permitted to try and deprive Dr. Marik of standing through a retaliatory, pretextual suspension that Sentara has kept secret from the Court"
They surveyed people in Mexico city, those who took Ivermectin and those who didnt
"The researchers found a reduction of between 52% and 76% in hospitalizations for those who took ivermectin compared to those who did not.
The government’s findings were corroborated by Dr. Juan J. Chamie-Quintero, a senior data analyst at private Colombian university EAFIT.
He found that excess deaths in the city dropped sharply only a few weeks after the ivermectin treatments began.
Chamie-Quintero also conducted a study in Peru, where the government approved ivermectin as a treatment for the virus in May 2020.
In the 24 Peruvian states that adopted early use of ivermectin treatment, excess deaths plummeted on average by 59% just 30 days after the peak death rate. And it had dropped 75% after 45 days in those over 60 years old.
‘Large, statistically significant reductions in mortality’
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