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From my (limited) observations, the worst places on 495 are near the Rte 3 interchange (always backs up on Rte 3 there, down to Billerica) and then near the I-290 interchange. But, I think overall the commute is quite easy, compared to other commutes in the region.
I used to do the reverse commute, headed north, and about 95% of the time it wasn't bad. Once in awhile I'd get on the highway and there'd be a huge accident and I'd be stuck there a long time but it wasn't terrible. And that's coming from someone who hates to drive!
No traffic going from Chelmsford to Northborough. Watch for speed traps on Route 290. ;-)
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