Your "debt to income" ratio will be based on the amount you owe OUTSIDE of your mortgage amount. Technically HELOC is a 2nd mortgage. If you truly do have "plenty of equity" and sell for more than you owe the existing mortgages will be settled and your equity will be yours to apply to a downpayment on your new house, or pocket if you are downsizing...
Your FICO can be excellent with a HELOC or lousy -- all depends on your total credit picture.
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