I commuted from Manchester, NH to Dedham, MA and that was not a fun commute because I had to deal with the Rt. 128 "Nightmare" which was always bad going both ways. You will have a lot of stop and go traffic around the stateline all the way to the Rt. 128 interchange. Of course the closer you get to Boston the worse that traffic gets. On average my drive time was 1 hour and 45 minutes each way with normal traffic congestion. This does not include accidents or Friday evenings during ski season.
As far as commuting from Boston to Manchester, NH, that would much better. Anyone who makes this commute wished they could be on the other side because there was hardly any traffic. In fact I knew several people that commuted to our NH office from the North Shore area and they said it was a piece of cake for the most part. Good luck .....