You can take the LIRR to Hempstead and then take a N70/71/72 or use a cab. Definitely use a cab leaving, though, since the buses probably won't run by the time the game is over. I don't know how much it would cost for a cab since I never use them. Getting to that area is a real pain, and I'd be surprised if there were any bus from as far away as Manhattan.
Tickets shouldn't be hard to get since Nassau Coliseum has had attendance problems for a while (lol suburban fanbase). The crowd there is also fairly tame compared to the other arenas in the league. I wouldn't worry about getting assaulted, although anything could still happen.
Some folks over on the Long Island forum may know more since you'll find people from Nassau county there.
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