Have you tried Facebook?
I know it's going to take a while but it happened to me when I was looking for a lost friend.
Your wife will start adding people that she knows; some could be common friends between your wife and that lost friend. As your wife's friend list builds up, FB will give her suggestions of people she wants to be friend with, from her friend's list. One could be her lost friend.
Also if she surfed on her friend's pictures, maybe a common friend would have their pictures together. And if she is lucky enough, that lost friend will be tagged. So your wife can contact her right away on her FB profile.
Finally, you can just google her friend's name on FB search box. If the lost friend happened to have a FB account, it will be there (assuming she put her real name or whatever nick name your wife called her as an alias).
Good luck!
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