Yes, we have a pair of rabbits (both neutered, and are siblings) when we got them they were small and both fit in 1 large cage (now we have 2 cages side to side so it's a long bunny cage with 1 of the smaller walls of each taken out so they can move between them when they "need" to be in the cage and not in their sectioned off room), we put the bedding/litter down all across the cage and saw where they chose to pee (back corner) put the litterbox with the bedding in that area and they immediately took to only using that area to use the bathroom. To clean the litterbox just use white vinegar, no chemicals, and use the more (for lack of a better term) puffy litter stuff, not cat litter or pine shavings as those can hurt their lungs.
If you let them run around your house make sure there are no cords in reach/not blocked as they'll chew through them. As for cutting the nails, the scissor type nail cutters (like
these but a bit bigger, we got ours at walmart for a couple dollars) or large toenail type cutters work best for ours, to make things really easy we give them a short bath before hand (just a few inches of water and while they aren't in love with the baths, they don't really mind, especially if it's warm or dry out) to soften the nails. Keep in mind they don't make noises (they'll thump a back leg once or twice if they're angry/scared, and grind their teeth if you're petting them as their way of purring) so can be a tad difficult to find if they go under furniture.
And they really seem to like it if you change their surroundings periodically, we use concrete form tubes (they sell them in various sizes at home depot and similar stores we get the 8 inch diameter for about 9 dollars they're like 4 feet long) and cardboard boxes with "doors" and "windows" cut in to change a 5x7 foot area sectioned off by those wire cube/shelf parts they are always able to run around in, so they have a lot of different elevations and area to play around in.
We love ours, and can't imagine living without them again