The ‘very, very bad look' of remdesivir, the first FDA-approved COVID-19 drug

[GuyNTexas]

Originally Posted by Hoonose

There may be patients in the world where Remdesivir may be available, and not other more substantive treatments. There may be patients even here in the USA where it may be the only or of a few Rx's on hand. And/or there may be conflicts like allergies or even insurance. It is not anyone's first choice in treatments.

You either don’t know what you are talking about, or being deliberately dishonest.

Throughout the entire pandemic, Remdesivir was the ONLY APPROVED TREATMENT for Covid in hospitals nationwide, and was not only the first option, but the only option, and was THE ESTABLISHED PROTOCOL.

Furthermore, many suspect it to be the primary cause of what was subsequently labeled Covid Pneumonia, leading to ventilation and death, because of Remdesivir’s propensity to cause renal failure at the dosages and course recommended.

If you are actually an MD, you should know that renal failure results in fluid building around the heart and in lungs, which could easily be mistaken as pneumonia.

To make the matter that much more suspect, and adding additional evidence to the theory that this was a deliberate means of increasing death counts to hype the fear, these bastards knew that if there was indeed any clinical benefit at all to using Remdesivir, it could only be useful in the early stages of the disease, and not useful at all in hospitalized patients. You see, Remdesivir’s declared mechanism of action is to disrupt viral replication, which would only make it potentially useful in the early stages when viral replication is occurring, and not in the late stages where viral replication has already waned.

So, like everything else, it’s once again the same old story … just one fraud stacked on top of another, and another.

[bluesjuke]

Originally Posted by Hoonose

Actually remdesivir showed promise as an early outpatient treatment, but never took off.
https://www.nejm.org/doi/full/10.1056/NEJMoa2116846

That "promise" turned out to be as good as Biden's on unity.

[Hoonose]

Originally Posted by AfricanSunset

Doing nothing is far better than giving someone Remdesivir.

I don't know why you keep ignoring the chart I show you, it does nothing re COVID, except cause renal damage.

And while it's not a guarantee your kidneys will fail, it's almost a guarantee they will be damaged at the subclinical or clinical level.

All the animals at all doses showed kidney damage on autopsy.

We treat patients (not animals) in real time using the most up to date therapy. There are risks with any therapy. Remdesivir has long since fallen by the wayside as first line treatment. Why are we wasting time on this? Where were you - not on this forum - while we discussed emerging emergent Covid 19 treatments in real time?

[Hoonose]

Originally Posted by Hrw-500

It could be interesting to compare the list of the ingredients who compose Remdesivir and Paxlovid. I wonder if they might probably share some of the same ingredients?

*-vir drugs are antivirals. The two are different antivirals.

[AfricanSunset]

Originally Posted by Hoonose

I have nothing in this hunt other than to relate the up to date medical opinions. Remdesivir was an early treatment choice when we had had next to nothing in 2020. It was never a gang buster remedy by any means, and of course did reveal more than its share of renal dysfunction. It has not been a first line drug of choice for Covid 19 for a long time now.

1. Remdesivir was an early treatment choice when we had had next to nothing in 2020

Only if you were hospitalized (now they expended it to outpatient, but I pray no one is doing that!), which ironically are the people who do worst with Remdesivir per the Solidarity+ in the Lancet you posted.

2. It was never a gang buster remedy by any means

Well, God almighty Fauci claimed it was a 'game changer' !

I keep repeating this and will keep repeating this: doing NOTHING is BETTER than giving your patients Remdesivir. Giving your patients Remdesivir is doing MORE harm than good in every case I can think of. Even if you give it to a young healthy adult, you just did some damage to their kidneys for no reason.

Remdesivir is just poison you're injecting into patients.

The only medical establishment to recommend it and go full throttle on it was the US medical establishment. Some Latin American countries followed our lead then discontinued it - like Brazil. But God almighty Fauci spoke, and therefore while the rest of the world shunned this, we kept giving it to COVID19 hospitilized patients well into 2021.

Europe nor Asia ever went on the Remdesivir train.

[AfricanSunset]

Originally Posted by Hoonose

*-vir drugs are antivirals. The two are different antivirals.

GS-441524, the active component in Remdesivir, is a DNA chain terminator, a mutagenic drug.

I don't get why scientists love creating mutagenic drugs to treat viral infections, especially DNA chain terminators.

Say NO to DRUGS, kids!