I usually park at the garage across from Marbles Museum. The R-Line is handy if you don't want to walk all over the place:
Get Around :: R-LINE :: Downtown Raleigh
Art Space gets very crowded but it is a good way to see a lot in just one stop. CAM is usually interesting. I particularly like Flanders Gallery a lot.
For food Raleigh Times has great sandwiches, Remedy Diner has delicious vegetarian options and Buku's small plate options can be reasonable if you have restraint! Sometimes I meet friends for an impromptu picnic at one of the parks before we hit the galleries. A stop by Neomondes before arriving downtown provides a nice array of finger food.
First Friday | Downtown Raleigh | Map