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I think there's a sign for the warehouse district just east of Duke st on Main. This is an area of old tobacco warehouses that are undergoing renovation--apartments mostly. Just west of this area is Brightleaf Square, which has some restaurants and shopping. I'm not sure is it's considered part of the warehouse district. I wouldn't exactly consider it a hub for nightlife.
I'd be interested to know what the long term plans are for this area--it's under serious construction at the moment...
Here is a link showing the Warehouse District of Downtown Durham on a map (in purple):
Downtown Durham Inc.: Getting Around (broken link)
The construction is called West Village - Phase 2, described more on this page from the Durham Convention & Visitors Bureau:
Durham, NC | (broken link)
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