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Old 03-19-2020, 01:22 PM
 
1,620 posts, read 1,749,244 times
Reputation: 810

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Some promising news about a potential cure for coronavirus

Malaria drug sees promising signs as future coronavirus treatment
https://www.google.com/amp/s/www.was...nt%3f_amp=true

** A drug originally developed to treat malaria is showing signs that it may also cure infections of the coronavirus, though much more testing is needed.

Researchers and virologists in France have completed a clinical trial studying the effects of hydroxychloroquine, used to treat arthritis, malaria, and other ailments, on patients with COVID-19. Researchers treated a total of 26 coronavirus patients with the drug, including six that were given the antibiotic azithromycin, as well.

The researchers released their findings in a study published on Wednesday. The results showed that all six patients treated with hydroxychloroquine and azithromycin tested negative for the virus after six days. Of the 20 treated with just hydroxychloroquine, 57.1% tested negative for the coronavirus after six days. Just 12.5% of the control group made up of 16 other patients tested negative.

"Despite its small sample size our survey shows that hydroxychloroquine treatment is significantly associated with viral load reduction/disappearance in COVID-19 patients and its effect is reinforced by azithromycin," the study said. **

----------------------------------------------------------

Trump says FDA will fast track anti-viral treatments but FDA chief says it could take 1 year
https://news.google.com/articles/CAI...S&ceid=US%3Aen

(CNN)President Donald Trump says he's pushed the Food and Drug Administration to eliminate barriers to getting therapeutics for coronavirus to patients.

He said a drug currently used as an antimalarial -- hydroxychloroquine -- would be made available almost immediately to treat coronavirus.

"It's been around for a long time so we know if things don't go as planned it's not going to kill anybody," Trump told reporters at the White House.

"We have to remove every barrier or a lot of barriers that were unnecessary and they've done that to get the rapid deployment of safe, effective treatments and we think we have some good answers," Trump said.

FDA Commissioner Stephen Hahn carefully tempered the President's remarks regarding his team's work to develop treatments for coronavirus.

"The FDA is committed to continuing to provide regulatory flexibility and guidance, but let me make one thing clear: the FDA's responsibility to the American people is to ensure that products are safe and effective," he said.
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Old 03-19-2020, 02:13 PM
 
Location: Sarasota/ Bradenton - University Pkwy area
3,699 posts, read 5,364,995 times
Reputation: 3824
Just saw this:

Beginning at 6am on March 20, the beaches in the City of Anna Maria will be closed until further notice. In addition, the city says restaurants can stay open but must seat patrons at least 6 feet apart and cannot seat a group of more than 10. Sarasota county government will be meeting to evaluate leaving Sarasota beaches open.


University Town Center mall is closing thru the end of the month, as are the South Gate & Sarasota Square malls in Sarasota. However, Costco is remaining open at this time. As of this post, the Desoto Square Mall in Bradenton remains open -- but since it's only major retail store left, JC Penney's, has closed thru the end of March, that only leaves a handful of small specialty shops open there anyway so they might as well close for the duration as well. Ellenton Outlet Mall has already closed down this week thru the end of March.

Last edited by Sunshine Rules; 03-19-2020 at 02:27 PM..
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Old 03-19-2020, 02:41 PM
 
Location: Sarasota, FL
609 posts, read 427,778 times
Reputation: 799
Sarasota and Manatee counties are closing their beaches starting 6am Saturday 3/21/2020. They said people have actually been in groups of 10 or less and six feet apart, but they were worried about an influx of more people due to other area beaches closing. FYI, and... ugh.
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Old 03-19-2020, 05:21 PM
 
9,598 posts, read 6,338,560 times
Reputation: 5531
Quote:
Originally Posted by wondermint2 View Post
Some promising news about a potential cure for coronavirus

Malaria drug sees promising signs as future coronavirus treatment
https://www.google.com/amp/s/www.was...nt%3f_amp=true

** A drug originally developed to treat malaria is showing signs that it may also cure infections of the coronavirus, though much more testing is needed.

Researchers and virologists in France have completed a clinical trial studying the effects of hydroxychloroquine, used to treat arthritis, malaria, and other ailments, on patients with COVID-19. Researchers treated a total of 26 coronavirus patients with the drug, including six that were given the antibiotic azithromycin, as well.

The researchers released their findings in a study published on Wednesday. The results showed that all six patients treated with hydroxychloroquine and azithromycin tested negative for the virus after six days. Of the 20 treated with just hydroxychloroquine, 57.1% tested negative for the coronavirus after six days. Just 12.5% of the control group made up of 16 other patients tested negative.

"Despite its small sample size our survey shows that hydroxychloroquine treatment is significantly associated with viral load reduction/disappearance in COVID-19 patients and its effect is reinforced by azithromycin," the study said. **

----------------------------------------------------------

Trump says FDA will fast track anti-viral treatments but FDA chief says it could take 1 year
https://news.google.com/articles/CAI...S&ceid=US%3Aen

(CNN)President Donald Trump says he's pushed the Food and Drug Administration to eliminate barriers to getting therapeutics for coronavirus to patients.

He said a drug currently used as an antimalarial -- hydroxychloroquine -- would be made available almost immediately to treat coronavirus.

"It's been around for a long time so we know if things don't go as planned it's not going to kill anybody," Trump told reporters at the White House.

"We have to remove every barrier or a lot of barriers that were unnecessary and they've done that to get the rapid deployment of safe, effective treatments and we think we have some good answers," Trump said.

FDA Commissioner Stephen Hahn carefully tempered the President's remarks regarding his team's work to develop treatments for coronavirus.

"The FDA is committed to continuing to provide regulatory flexibility and guidance, but let me make one thing clear: the FDA's responsibility to the American people is to ensure that products are safe and effective," he said.

Great information. If the French study is legitimate, the FDA must get off its high horse and allow the immediate use of these drugs. Both drugs have already been tested for safety given their use to treat other diseases. The Trump administration quickly should be able to push this drug regimen for general use to treat COVID-19 if it actually now understands the threat facing the nation is a crisis, both to the nation's health and economy.


https://www.usatoday.com/in-depth/ne...ms/5009057002/

Last edited by WRnative; 03-19-2020 at 05:37 PM..
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Old 03-19-2020, 09:54 PM
 
20,975 posts, read 6,380,843 times
Reputation: 13966
Quote:
Originally Posted by WRnative View Post
Great information. If the French study is legitimate, the FDA must get off its high horse and allow the immediate use of these drugs. Both drugs have already been tested for safety given their use to treat other diseases. The Trump administration quickly should be able to push this drug regimen for general use to treat COVID-19 if it actually now understands the threat facing the nation is a crisis, both to the nation's health and economy.

https://www.usatoday.com/in-depth/ne...ms/5009057002/
All decent news BUT, things are more complex than they seem.........

My daughter takes one of those drugs for an auto-immune disorder.

There is a difference between giving a drug to a few hundred thousand or a million people and giving it to 10's of millions...more drugs and types of people and conditions that it can react to and with.

Then there is the production capability - and decisions as to who is going to get it.

Remember, MANY (too many) Americans truly believe vaccines damage people....cause autism, etc....and that is with vaccines and drugs tested over literally billions of doses.

Even if everything is a "best case" scenario (and my daughter says the anti-malarial is super safe according to her doc).....these things do not appear by the billions of doses in a few weeks.

I did tell her to stash some pills away and maybe call her doc for another 90 days worth.

At this point (not before, but now and forward) I think there are enough people involved outside the admin (those that really matter and do things and know things) that promising drugs with few or no side effects will not face too many obstacles.

Still, getting our hopes up too quickly is probably not a good thing....our fear is what can help us stay safe by isolating.

Even if these things come out, that is not going to save everyone. Neither will a vaccine in a year or more...as Fauci said today, that vaccine is for the 2nd wave.

I've been through this same type of thing with a loved one with a genetic disease. They know so much and they do so many tests and trials...and 20 year back we were hopeful, but 20 years have gone by with almost zero in terms of an effective cure or slowdown.

This will likely be a quicker deal only because the entire world is working on it. That is a truly amazing thing to see because the combined intelligence of mankind is quite vast.
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Old 03-19-2020, 09:56 PM
 
1,620 posts, read 1,749,244 times
Reputation: 810
Donald Trump announced the FDA approved chloroquine to be used on a "compassionate use" basis on March 19.


https://www.youtube.com/watch?v=GKBydiPOcQc
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Old 03-19-2020, 10:37 PM
 
1,620 posts, read 1,749,244 times
Reputation: 810
Quote:
Originally Posted by wondermint2 View Post
Donald Trump announced the FDA approved chloroquine to be used on a "compassionate use" basis on March 19.
Sometimes called “compassionate use”, expanded access is a potential pathway for a patient with an immediately life-threatening condition or serious disease or condition to gain access to an investigational medical product (drug, biologic, or medical device) for treatment outside of clinical trials when no comparable or satisfactory alternative therapy options are available.

Expanded Use (Compassionate Use) as explained in detail on the FDA web site:
https://www.fda.gov/news-events/publ...xpanded-access

------------------------------------------------------------

And keep in mind while some early limited testing with hydroxychloroquine on coronavirus looks promising - it's still considered experimental and hasn't undergone large scale testing yet (for coronavirus). There hasn't been a randomized clinical trial yet.

https://www.rollcall.com/2020/03/19/...ovid-19-drugs/

** Sanofi, which makes the combination drug used in the French pilot study, said more research is needed.

"Keep in mind it is very important to highlight that to date there is insufficient clinical data to draw any final conclusions over the clinical efficacy or safety of hydroxychloroquine (or chloroquine) in the management of COVID-19," said spokesperson Ashleigh Koss. **

Last edited by wondermint2; 03-19-2020 at 10:58 PM..
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Old 03-20-2020, 01:19 PM
 
Location: Sarasota/ Bradenton - University Pkwy area
3,699 posts, read 5,364,995 times
Reputation: 3824
I've received emails from 2 of the local builders this week stating their model homes will remain open but that they will no longer allow walk in traffic, everyone has to make appointments. They also want us agents to "screen" our buyers before bringing them, to ask if anyone has been out of the country recently or exposed to anyone with cold/flu symptoms in the past 14 days, and ask us to practice social distancing on the appointments.


That got me thinking. A lot of what Americans are being asked to do in the attempt to stop the spread of coronavirus really comes down to the "honor system." That people are going to self quarantine, not lie about exposure, wash their hands, etc.



Meanwhile, Governor Ron Desantis issued an executive order on Friday to suspend the sale of food and alcohol at restaurants and close all gyms statewide. DeSantis took additional action in Broward and Palm Beach counties, closing all movie theaters, concert houses, auditoriums, playhouses, bowling alleys, arcades, gymnasiums, fitness studios and beaches through March 31 due to a sharp increase in coronavirus cases there. I am wondering how well the honor system is actully working.........

Last edited by Sunshine Rules; 03-20-2020 at 02:19 PM..
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Old 03-20-2020, 03:26 PM
 
Location: Sunshine state
2,256 posts, read 3,138,862 times
Reputation: 3275
Quote:
Originally Posted by Sunshine Rules View Post
Governor Ron Desantis issued an executive order on Friday to suspend the sale of food and alcohol at restaurants.
I couldn't care less about the alcohol, but the food? Can we at least order to go?

And no beach?? I think as long as people maintain safe distance, beaches / parks / outdoor areas should be ok since there's fresh air at all times. Of course, some young jacka$$es had to party at the beach and ruined it for everyone, so now it's close for all of us.
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Old 03-20-2020, 03:40 PM
 
1,620 posts, read 1,749,244 times
Reputation: 810
Quote:
Originally Posted by wondermint2 View Post
Sometimes called “compassionate use”, expanded access is a potential pathway for a patient with an immediately life-threatening condition or serious disease or condition to gain access to an investigational medical product (drug, biologic, or medical device) for treatment outside of clinical trials when no comparable or satisfactory alternative therapy options are available.

Expanded Use (Compassionate Use) as explained in detail on the FDA web site:
https://www.fda.gov/news-events/publ...xpanded-access

------------------------------------------------------------

And keep in mind while some early limited testing with hydroxychloroquine on coronavirus looks promising - it's still considered experimental and hasn't undergone large scale testing yet (for coronavirus). There hasn't been a randomized clinical trial yet.

https://www.rollcall.com/2020/03/19/...ovid-19-drugs/

** Sanofi, which makes the combination drug used in the French pilot study, said more research is needed.

"Keep in mind it is very important to highlight that to date there is insufficient clinical data to draw any final conclusions over the clinical efficacy or safety of hydroxychloroquine (or chloroquine) in the management of COVID-19," said spokesperson Ashleigh Koss. **
I came across a cautionary article about chloroquine:

Virus drug touted by President Trump, Elon Musk can kill with just two gram dose:
https://news.google.com/articles/CAI...S&ceid=US%3Aen

** a Wuhan Institute of Virology study found that the drug can kill an adult just dosed at twice the daily amount recommended for treatment, which is one gram.

The drug is known to have short-term side effects such as nausea, diarrhea and tinnitus while long-term use can irreversibly impair eyesight. It’s forbidden for pregnant women as it can cause congenital defects in babies.

China Health Commission revised the dosage in a Feb. 29 notice tightening chloroquine use. The drug cannot be given to pregnant women, those with heart disease, terminal liver and renal disease, retina and hearing loss and patients on antibiotics such as azithromycin and steroid.

It can now be given only to patients between 18 to 65 years of age for a seven-day treatment course. Patients weighing over 50 kilograms (110 pounds) can take 500mg twice a day — the usual dose — while those weighing less will be administered the drug just once a day after two days of use, according to the latest guidelines. **
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