U.S. CitiesCity-Data Forum Index
Covid-19 Information Page
Go Back   City-Data Forum > General Forums > Science and Technology
 [Register]
Please register to participate in our discussions with 2 million other members - it's free and quick! Some forums can only be seen by registered members. After you create your account, you'll be able to customize options and access all our 15,000 new posts/day with fewer ads.
View detailed profile (Advanced) or search
site with Google Custom Search

Search Forums  (Advanced)
Reply Start New Thread
 
Old 08-22-2012, 06:20 PM
 
Location: Texas
5,070 posts, read 9,162,666 times
Reputation: 1632

Advertisements

Enzymes involved in breaking down fat can now be manipulated to work three times harder by turning on a molecular switch recently observed by chemists at the University of Copenhagen. Being able to control this chemical on/off button could have massive implications for curing diseases related to obesity including diabetes, cardio vascular disease, stroke and even skin problems like acne. But the implications may be wider.
Reply With Quote Quick reply to this message

 
Old 08-23-2012, 09:13 AM
 
Location: Londonderry, NH
41,478 posts, read 52,760,224 times
Reputation: 24677
link?
Reply With Quote Quick reply to this message
 
Old 08-23-2012, 09:51 AM
 
13,138 posts, read 37,313,295 times
Reputation: 12153
As an lifelong athlete i've studied Cellular Respiration over the years and know this process well and so i have some issues with the study authors after reading the posted article. I noticed that they didn't name the specific ''enzymes'' that were involved in their research as there are 100's of different types of lipase enzymes involved in the breakdown of fatty acids into energy (ATP) via 3 cycles which are Beta Oxidation, Citric Acid Cycle and the Electron Transport Chain.

All humans individually have a set basal metabolic rate that produces the needed amount of ATP that fuels the entire body and so trying to manipulate that process to further add ATP hence the burning of more fat could backfire as where would the body transport all that extra ATP (electrons) that's not needed? It likely would cause over heating of the cell(s) hence possible cell death hence human death as the body prefers a tight range of 98.6 F.

So forget the so called ''fat burners'' and just crank up the exercise as that'll crank out the breaking down of stored fat for ATP via Beta Oxidation .
Reply With Quote Quick reply to this message
 
Old 08-23-2012, 11:54 AM
 
Location: Pueblo - Colorado's Second City
12,213 posts, read 21,576,226 times
Reputation: 4300
I have read that by the middle of the next decade we will be able to eat what we want and gain no weight. This is just one more step to that goal.
Reply With Quote Quick reply to this message
 
Old 08-24-2012, 10:08 AM
 
5,366 posts, read 8,359,724 times
Reputation: 3407
Quote:
Originally Posted by GregW View Post
link?
The text in the op is hotlinked to the article. Just click the text.
Reply With Quote Quick reply to this message
 
Old 08-24-2012, 10:56 AM
 
Location: Victoria TX
42,662 posts, read 76,357,401 times
Reputation: 36232
Quote:
Originally Posted by Josseppie View Post
I have read that by the middle of the next decade we will be able to eat what we want and gain no weight. This is just one more step to that goal.
Bulimics already do that, using simple physiological principles known to the cavemen.
Reply With Quote Quick reply to this message
 
Old 08-24-2012, 06:00 PM
 
Location: Pueblo - Colorado's Second City
12,213 posts, read 21,576,226 times
Reputation: 4300
Quote:
Originally Posted by jtur88 View Post
Bulimics already do that, using simple physiological principles known to the cavemen.
I have no desire to be a bulimic as it is unhealthy.
Reply With Quote Quick reply to this message
 
Old 08-24-2012, 07:14 PM
 
Location: Texas
5,070 posts, read 9,162,666 times
Reputation: 1632
Quote:
Originally Posted by 6 Foot 3 View Post
As an lifelong athlete i've studied Cellular Respiration over the years and know this process well and so i have some issues with the study authors after reading the posted article. I noticed that they didn't name the specific ''enzymes'' that were involved in their research as there are 100's of different types of lipase enzymes involved in the breakdown of fatty acids into energy (ATP) via 3 cycles which are Beta Oxidation, Citric Acid Cycle and the Electron Transport Chain.

All humans individually have a set basal metabolic rate that produces the needed amount of ATP that fuels the entire body and so trying to manipulate that process to further add ATP hence the burning of more fat could backfire as where would the body transport all that extra ATP (electrons) that's not needed? It likely would cause over heating of the cell(s) hence possible cell death hence human death as the body prefers a tight range of 98.6 F.

So forget the so called ''fat burners'' and just crank up the exercise as that'll crank out the breaking down of stored fat for ATP via Beta Oxidation .
Suppose they just put it at a bit above 98.6 F to 99.6F for a specified amount of time? I do understand that too much is bad for a person. But then there are people who just cannot exercise like a regular person.
Reply With Quote Quick reply to this message
 
Old 08-25-2012, 06:39 AM
 
13,138 posts, read 37,313,295 times
Reputation: 12153
Quote:
Originally Posted by Brian.Pearson View Post
Suppose they just put it at a bit above 98.6 F to 99.6F for a specified amount of time? I do understand that too much is bad for a person. But then there are people who just cannot exercise like a regular person.
That's a great question although i'll have to defer that to someone more qualified than myself e.g. a physician, as i'd thinkl that even raising the bodies temp by one degree long term ''could'' cause damage somewhere. BTW the body does during certain situations artificially produce added heat as that usually occurs when ill from certain bacteria/viruses in the form of a fever and also when the body temp begins to drop dangerously low for example when exposed to cold weather (hypothermia).

As for exercising to lose fat well one does not need to do that to lose weight as diet alone can accomplish that however it's an added bonus in speeding up the breakdown of fat (lipolysis).

Sidenote: i'm not sure why however the cells really seem to prefer to burn short chain and medium chain fatty acids over what most of us consume daily (meat, plants) which are long chain fatty acids. Might be part of the reason people seem to have more energy when consuming long term coconut oil (medium chain) and even butter (short chain) .
Reply With Quote Quick reply to this message
 
Old 08-25-2012, 11:34 AM
 
Location: Texas
5,070 posts, read 9,162,666 times
Reputation: 1632
It could also be that the temperature could be held down to a more normal and just wait for the enzymes to do its stuff. As it stands, my wife likes it cooler and I have to have something to cover me so I can feel "normal" and so she can be "normal". Lots of normals out there...
Reply With Quote Quick reply to this message
Please register to post and access all features of our very popular forum. It is free and quick. Over $68,000 in prizes has already been given out to active posters on our forum. Additional giveaways are planned.

Detailed information about all U.S. cities, counties, and zip codes on our site: City-data.com.


Reply
Please update this thread with any new information or opinions. This open thread is still read by thousands of people, so we encourage all additional points of view.

Quick Reply
Message:

Over $104,000 in prizes was already given out to active posters on our forum and additional giveaways are planned!

Go Back   City-Data Forum > General Forums > Science and Technology
Similar Threads
Follow City-Data.com founder on our Forum or

All times are GMT -6.

© 2005-2020, Advameg, Inc. · Please obey Forum Rules · Terms of Use and Privacy Policy · Bug Bounty

City-Data.com - Archive 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35 - Top