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One route is to take I-10 to I-65 to I-85 to I-95. This passes through MS, AL, GA, SC, NC, VA, DC, MD, DE, PA and NJ, before New York finally shows up. My understanding that this is a truck-heavy route.
Another route is to take I-10 to I-95, which crosses into New York via the George Washington Bridge. It's a simpler route but adds 200 miles to the itinerary. This passes through one more state than the previous route - FL. Is this route worth the extra 200 miles because there are fewer big rigs on the roads?