I don't consider a 6 hr drive a "long distance move."
We moved in 2005 from Portland, OR to Greenville, NC. Had never been south of New Jersey before our first visit to check out the area. Have no family nearby - closest is in NJ, with most in Utah, Nevada, and Washington State. Didn't know a soul in NC when we moved.
We love North Carolina. Greenville was too small for my wife; we have since moved just south of Winston-Salem. Ideally, we'd be closer to family, but this is apparently where we're supposed to be at this time.