Nanoparticles detect biochemistry of inflammation (signal, function, issue)

[Brian.Pearson]

Inflammation is the hallmark of many human diseases, from infection to neurodegeneration. The chemical balance within a tissue is disturbed, resulting in the accumulation of reactive oxygen species (ROS) such as hydrogen peroxide, which can cause oxidative stress and associated toxic effects.



Although some ROS are important in cell signaling and the body's defense mechanisms, these chemicals also contribute to and are indicators of many diseases, including cardiovascular dysfunction. A non-invasive way of detecting measurable, low levels of hydrogen peroxide and other ROS would provide a viable way to detect inflammation. Such a method would also provide a way to selectively deliver drugs to their targets.