I was always wondering if someone could open a plane door in flight.
There are a couple of reasons for this, but the big one is cabin pressure which, in effect, seals the doors shut. Plus many aircraft doors are "plug-type" in design meaning the doors are bigger than the opening (unless they are rotated). Again, though, once cabins begin to pressurize, which occurs as the plane begins to taxi, well - forget it. Those doors are shut.
The Myths of Flying: Can You Open Jet Door? - ABC News