As a former expediter running an E-350 7.3 diesel I can attest to the fact that synthetic oil is a terrific choice. I averaged 3000 lbs in the back of the van with an average speed of 70 mph. I changed the oil every 15,000 miles and realized approx. an increase of 3-5 mpg over the conventional oil. Furthermore, I read a testimony of a driver in Tenn. who pulled a 5th wheel with a Ford truck and after changing his transmission to ATF by Amsoil dropped his transmission temp from 270 degrees to 215 degrees. Extended drain intervals can be realized by taking advantage of the oil analysis programs available as well.
Synthetics are a good choice for any mechanically sound engines or transmissions. I have been using them for well over 15 years.
Get more info at
www.buythebestoil.com or google the 3000 oil myth