Will ceramides become the new cholesterol? Seems like altering the ceramide/sphingomyelin ratio so that less ceramide accumulates in the body could be a solution to a lot of metabolic issues including adult onset diabetes. Just posting this to bring awareness to this new to me lipid and prompt some discussion.
https://www.theatlantic.com/health/a...ic-fat/518976/
"The team fed two sets of test animals a high-fat, high-sugar diet, but reduced the ceramide production in the second group by supplementing them with myriocin, a known ceramide inhibitor. At the end of the 12-week test period, the first group of animals predictably gained weight and became diabetic while the second group did not, despite consuming the same high-fat, high-sugar diet."
https://news.byu.edu/news/research-s...own-metabolism
Sanford Burnham Prebys Medical Discovery Institute (SBP) researchers have discovered that accumulation of a type of lipid (fat), known as ceramides, plays a crucial role in lipotoxic cardiomyopathy (LCM)—a heart condition that often occurs in patients with diabetes and obesity. The study, described in a new paper published today in Cell Reports, also identified several potential therapeutic targets that could prevent or reverse the effects of LCM.
https://www.sbpdiscovery.org/press/c...-heart-disease
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