Please register to participate in our discussions with 2 million other members - it's free and quick! Some forums can only be seen by registered members. After you create your account, you'll be able to customize options and access all our 15,000 new posts/day with fewer ads.
The drug, called tirzepatide, works on two naturally occurring hormones that help control blood sugar and are involved in sending fullness signals from the gut to the brain.
Researchers noticed that people who took the drug for their diabetes lost weight. The new trial focused on people who have obesity without diabetes and found even more weight loss.
Those taking the highest of three studied doses lost as much as 21% of their body weight – 50-60 pounds in some cases.
Nothing has provided that kind of weight loss except surgery, said Dr. Robert Gabbay, chief scientific and medical officer for the American Diabetes Association.
Quote:
Another obesity treatment approved last year called semaglutide, from Novo Nordisk, provides an average of up to about 15% weight loss. Previous generations of diet drugs cut only about 5% of weight and many carried prohibitive side effects.
"We've not had tools like this," Gabbay said. "I think it's really exciting."
For most of the trial participants, side effects from tirzepatide were not serious, said Jeff Emmick, vice president of product development for the diabetes division of drug giant Lilly, which makes the drug.
Well, that is some great news for people who are predisposed to developing type 2. The question is, did the participants who lost the weight also reverse their type 2 diabetes and will their metabolisms adapt to the drugs over time resulting in them regaining at least some of the weight that they lost. The "thrifty gene" is a stubborn one.
They "treat" it with another drug. What a surprise.
Why not use nutrition instead? Well...I know why. There is no money to be made.
While I agree, I'm sure plenty of people would pay $1,000 a month for a drug, if it would allow them to stay thin without having to work out or watch their nutrition intake!
The efficacy and safety of tirzepatide, a novel glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist, in people with obesity are not known.
As we've seen with the clot shots and the dozens of drugs that have been recalled or given a black-box warning over the past several years, the bit about unknown safety is a serious concern.
The efficacy and safety of tirzepatide, a novel glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist, in people with obesity are not known.
As we've seen with the clot shots and the dozens of drugs that have been recalled or given a black-box warning over the past several years, the bit about unknown safety is a serious concern.
Very true, I'm sure most of us are old enough to remember Fen-Phen (Fenfluramine/phentermine).
One of the roles of these drugs is to signal the satiety center in the brain that "We're full- Don't eat any more."...Diabetics seem to have an altered incretin secretion response.
These drugs have been around for more tha 10 yrs and from the beginning it's been known that they help with weight loss in diabetics....The question becomes whether or not they also cause weight loss/appetite control in non-diabetics, and is the benefit worth the side effect profile and cost?
One of the roles of these drugs is to signal the satiety center in the brain that "We're full- Don't eat any more."...Diabetics seem to have an altered incretin secretion response.
These drugs have been around for more tha 10 yrs and from the beginning it's been known that they help with weight loss in diabetics....The question becomes whether or not they also cause weight loss/appetite control in non-diabetics, and is the benefit worth the side effect profile and cost?
That’s what the new study look at:
Quote:
Researchers noticed that people who took the drug for their diabetes lost weight. The new trial focused on people who have obesity without diabetes and found even more weight loss.
I think the real question now is the second part of what you asked, whether the benefits outweigh the costs in terms of both side effects and costs. These drugs impact the endocrinological system and I know for at least the semaglutide cancer is one of the potential risks. I imagine the tirzepatide also has some of its own serious risks.
__________________
When I post in bold red that is moderator action and, per the TOS, can only be discussed through Direct Message.
Moderator - Diabetes and Kentucky (including Lexington & Louisville)
Please register to post and access all features of our very popular forum. It is free and quick. Over $68,000 in prizes has already been given out to active posters on our forum. Additional giveaways are planned.
Detailed information about all U.S. cities, counties, and zip codes on our site: City-data.com.
Please register to participate in our discussions with 2 million other members - it's free and quick! Some forums can only be seen by registered members. After you create your account, you'll be able to customize options and access all our 15,000 new posts/day with fewer ads.
