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If they are loyal party members they will not. It is a death wish. Carter being challenged by Kennedy in 80, Bush being challenged in 92: we know how both elections ended up. Of course in the case of Bush, we later had Perot. That was the last nail in the coffin for Bush.
Will any Republicans be challenging Trump for the WH? It's rare but it can happen (like Pat Buchanan Challenging Bush in 1992).... what do you think?
They learned their lesson last time around. Some, like Jeb, are still licking their wounds.
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