OK Bogota, I'll chime in since nobody has just yet...
My family and I are looking to move to the Greenville area in February 2008. My wife is heavily involved in the local Mom's Club (
International MOMS Club) here in Chattanooga. The organization is great and we have met a lot of wonderful families. I know there are FIVE Mom's Club chapters in the Greenville-Spartanburg area. Additionally, check out also Meetup.com - they have several mom's groups in the area (one with 145 members:
The Greenville Stay At Home Moms Meetup Group (Greenville, SC) - Meetup.com). Lastly, you may also want to check out Upstate Moms (
UpstateMoms.com | Where Moms Connect). They have a wonderful website (with a forum also).
Take care