After seeing this thread go along, it sounds to me like you truely feel that Greenville is the place for you.
Another part of the equation on the "leap of faith", is this....Are you willing to do what it takes to "make" it happen. I'm talking, living on beans and rice and delivering pizzas at night if necessary. Dumping the cell phones and cable tv (yes, I'm a big Dave Ramsey fan).
I've had to make those sorts of decisions to keep things afloat at times. That's part of why I'm comfortable making the leaps when necessary.
Remember this too, life has a way of grabbing hold of you and keeping you places. I didn't learn that until this last move. Fortunately, I got held in Greenville.
If I were to do it over again, I would have given more thought to where I was moving, because I could have been stuck in some miserable places.
In regards to the market here. This is really general, but....if I were to loose my job I'm very confident that I could find something, in a matter of a month or two that would pay our bills. Might not be in my field, and might not be what I want, but the bills would get paid.
Best wishes on figuring it all out. It's not easy.