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I don't think you would have too many problems at that hour, using the Harlem River and East River Drives. I would not expect huge disruptions on the WSH/HH Parkway that could cause problems nearer the bridge, just a mess if you were headed crosstown in Midtown.
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All the world's a stage, and all the men and women merely players: they have their exits and their entrances; and one man in his time plays many parts, his acts being seven ages.
~William Shakespeare (As You Like It Act II, Scene VII)
You should be OK in Manhattan...I'd be more worried about the GWB (the GWB approach in NJ often gets traffic jams worse than anything in the five boroughs, I find), but I suppose by then most people will already be wherever they are going.
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