The north side tends to be the most decayed, but there are some nice neighborhoods raising up there.
What's New in Old North
There are people currently working to save Old North St. Louis.
I don't think St. Louis has an empty building as interesting as the book Depository. There are some north riverfront empty buildings I believe. Washington Ave. has seen a lot of renovations in recent years. Most have been redone, are in the process of, or at least have a plan attached.
Built St. Louis: Home
That site is really interesting, though not as up-to-date when it comes to Wash. Ave. Paul McKee is buying up homes in North St. Louis, letting them deteriorate (taking the windows out) and then demolishing them. He's trying his best to destroy North St. Louis (see the Built St. Louis blog) or here:
Ecology of Absence
The World of Blairmont
There are abandoned buildings in St. Louis certainly, I'm not sure of one as interesting as the Book Depository of Michigan Central Station. At least not anymore.
For that Built St. Louis site, under crumbling landmarks:
The Switzer building is gone, a storm destroyed more of it in 2006, meaning not enough was left to qualify for historic tax credits. The loft plan was abandoned and the building was knocked down the rest of the way.
City Hospital is now the Georgian Condominiums
The Georgian
The Arcade Building I believe is under construction.
The Arcade | Classic Luxury Residential Condos and Lofts in St. Louis Missouri
The Syndicate-Trust building is in use as condos
Syndicate - Located in Downtown St. Louis, MO 63101
The Keil Opera House, which is owned by Blues owner Dave Checketts, is under a plan for a $50 million renovation expected to be done by 2010. The Opera House Auditorium was demolished in the 90s to build Scottrade Center, but the rest of the massive building still stands.
Carr School I think has a plan underway, but I can't find anything about it online.
Cass Avenue Bank is still standing, I don't know anything beyond that.
Clemens Mansion is still in a sad state. Paul McKee, who owns it and has apparently done nothing with it during that time, sent some workers a while back to repair it. The police stopped them. Apparently they didn't have the correct permits.
Avalon Cinema appears to not be changing any time soon.
Franklin school -
Franklin School Apartments - Active Senior Living, Downtown St. Louis
MacArthur Bridge - as far as I know there's been no change.
Recalled to life:
Continental building -
Continental Life Building, Luxury Apartment and Loft homes in Midtown St. Louis
St. Louis state hospital is partially a museum
http://www.mimh.edu/library/about.htm
Chase Hotel -
Chase Park Plaza
Cupples Station Warehouses - there are many in St. Louis. One is next to Busch Stadium and I believe is the Westin. Another one nearby is being worked on. And there are Cupples Station Apartments.
Cupples Station Loft Apartments
Westin St. Louis Hotels: The Westin St. Louis - Hotel Rooms at Westin.com.com
There are more Cupples buildings, some under construction. Near Busch Stadium's MetroLink station, standing at the Busch gate you can see old windows facing the inside of the MetroLink tunnel. Those were most likely from a demolished Cupples Station building.
Eads Bride - you can walk and drive across it (I've walked across it and under it).
Historic Bridges of the U.S. | Eads Bridge
Merchandise Mart -
Merchandise Mart Apartments
Neighborhood Gardens -
NEIGHBORHOOD GARDENS APARTMENTS - Home
Paul Brown Building -
The Paul Brown Loft Apartments
Homer G. Phillips hospital - Senior Citizen apartments
Homer G. Phillips senior center has waiting list - St. Louis Business Journal:
South Side National Bank -
South Side Tower | St. Louis, Missouri
Statler Hotel - Renaissance Grand. I've stayed there before. It's nice. The Renaissance is two towers, the Statler and a skinnier hotel that was also renovated. The Mayfair, a historic hotel, is also nearby.
Saint Louis Hotel: Renaissance Grand & Suites Downtown St. Louis Hotel
The "windows" on the back of the Suites tower are mostly painted on.
Unfortunately (as you probably know) Detroit's Statler is gone.
International Fur Exchange - Drury Plaza Hotel
Drury Plaza Hotel, St. Louis, Missouri
Moolah Temple - A movie theater/lounge/bowling alley/apartments now.
Moolah Theatre & Lounge
Moolah Lanes - Home