I am glad you brought this up Joe as I have been meaning to add a couple of places we ventured into during the Lancaster County Art & Ag Tour.
Located right on Main St in Lancaster is
Chastain's Studio Lofts. This place is really nice, unpretentious, and everyone is very welcoming. They have several artists that create and show their work here, they also offer adult and kid art classes, and on certain nights of the week they have live entertainment. They are a place of business that really gives back to the community and others with various fundraisers throughout the year (this is something the owner if very proud of). Stop in sometime I think you'll be pleasantly surprised.
Chastain's Studio Lofts
Then just off of Main St. in downtown Lancaster is
Bob Doster's Backstreet Studio. I was familiar with Mr. Doster's artwork as he does a lot with our local schools (sharing his time and creativity with the kids). His studio is best described as funky and fun, not stuffy at all, and just a great combination of fellow artists expressing themselves (it's like NODA meets Lancaster, SC).
Bob Doster