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Dr. Stephen O' Rahilly ( a University of Cambridge obesity researcher who knows Dr. Jeffrey Friedman well) has estimated that 1 in 1,000 people carry a mutation in the MC4 receptor (in the brain) and are obese as a result.
That means worldwide, there'll be hundreds of thousands of people like this, with this disorder, so it's NOT by any means rare, and it's certainty commoner than some well - known genetic disorders such as muscular dystrophy and cystic fibrosis.
Last edited by RickSantos; 01-29-2013 at 02:06 PM..
What Rick fails to mention is that the receptor works by an effect on appetite.
There is nothing magic going on. People with the abnormality eat more.
It is a line of active research. People are looking for compounds that might block the effect the abnormal receptor has on eating and help people lose weight --- by eating less.
What Rick fails to mention is that the receptor works by an effect on appetite.
There is nothing magic going on. People with the abnormality eat more.
It is a line of active research. People are looking for compounds that might block the effect the abnormal receptor has on eating and help people lose weight --- by eating less.
Dr. Stephen O' Rahilly ( a University of Cambridge obesity researcher who knows Dr. Jeffrey Friedman well) has estimated that 1 in 1,000 people carry a mutation in the MC4 receptor (in the brain) and are obese as a result.
That means worldwide, there'll be hundreds of thousands of people like this, with this disorder, so it's NOT by any means rare, and it's certainty commoner than some well - known genetic disorders such as muscular dystrophy and cystic fibrosis.
Yeah Rick some people have always been fat--even in the old days. They're probably the ones who survived the famines so it's possible that the gene is more common than it was 10K years ago.
What Rick fails to mention is that the receptor works by an effect on appetite.
There is nothing magic going on. People with the abnormality eat more.
It is a line of active research. People are looking for compounds that might block the effect the abnormal receptor has on eating and help people lose weight --- by eating less.
What Rick fails to mention is that the receptor works by an effect on appetite.
There is nothing magic going on. People with the abnormality eat more.
It is a line of active research. People are looking for compounds that might block the effect the abnormal receptor has on eating and help people lose weight --- by eating less.
THERE ARE PLENTY OF VERY OVERWEIGHT PEOPLE WHO EAT NORMAL PORTIONS, NUTRIENT DENSE AND EXERCISE REGULARLY BUT REMAIN FAT.
FURTHERMORE, YOU COULD HAVE 2 PEOPLE , THE SAME AGE, SEX, HEIGHT AND WEIGHT - BOTH DOING THE EXACT SAME WORKOUT AND EATING THE SAME NUMBER OF CALORIES- AND THE RESULTS WOULBE BE VERY DIFFERENT.
YOU MAKE A LOT OF UNEDUCATED ASSUMPTIONS ABOUT OBESITY.
THERE ARE PLENTY OF VERY OVERWEIGHT PEOPLE WHO EAT NORMAL PORTIONS, NUTRIENT DENSE AND EXERCISE REGULARLY BUT REMAIN FAT.
FURTHERMORE, YOU COULD HAVE 2 PEOPLE , THE SAME AGE, SEX, HEIGHT AND WEIGHT - BOTH DOING THE EXACT SAME WORKOUT AND EATING THE SAME NUMBER OF CALORIES- AND THE RESULTS WOULBE BE VERY DIFFERENT.
YOU MAKE A LOT OF UNEDUCATED ASSUMPTIONS ABOUT OBESITY.
LEARN FROM REGAN CHASTAIN.
Obviously two people could have the same height and weight but different body composition and respond differently to the same diet and exercise plan because of different basal metabolic rates. But that is the wrong comparison. What we need to know is what happens when an individual who is stable at a given weight reduces intake. No matter what the initial BMR is, weight loss will occur. With continued weight loss, the BMR will change, usually decreasing. Maintaining muscle mass helps mitigate the decrease in BMR. Over time, even small effects add up. Caloric intake has to be modified to account for the changing BMR.
Whether the weight loss is maintained is a complex process in which many factors play a part. Extreme examples of eating disorders are anorexia nervosa and bulimia. They show the effect of psychological influences on eating patterns.
Last edited by suzy_q2010; 01-30-2013 at 03:57 PM..
Rick if you would stop "yelling" at us and blaring your announcements in garish colors like a cheap advertisement, you'd probably get a greater quantity of thoughtful responses, though I must say that these folks have been exceptionally polite and reasonable. You actually make some pretty good points, but telling people they're idiots is probably gonna get you ignored. Type in small letters, don't underline them and confine them to one color and don't tell people, esp docs, that they don't know anything and see if you don't get a better response. I was going to send this to you in a DM but then decided that you've probably embarrassed yourself far more than I ever could.
That said, studies have shown that people really do have different metabolic rates and that how much you eat is not a perfect direct correlation with your weight, but in general you can lose weight by eating less and exercising more--you just have to try harder than thin people and you have to experiment to find out what works for you. The theory about gut bacteria has some merit I believe and wheat sensitivity and blood sugar swings surely have an effect so working with those should be part of the experimentation process. That's why I always shake my head when they get in an argument here about which diet is best--which diet is best for whom? Only you know what changes you can live with for the rest of your life and Atkins is probably not going to work for a staunch vegan but will work marvellously for the gluten intolerant.
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