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If you want a good picture for how it works, then imagine that your skin is a rubber balloon that will adapt to whatever is in it.
When you add fat you are going to be adding a kind of gel into this, it's a very slow flowing fluid, and the balloon with disperse it throughout your body through it's elasticity. when you burn calories with any muscle in your body, it will take from the surrounding fat, and as there is less "fat-gel" to press together for the balloon it will immediately and automatically push together the gel to a new fit, meaning the net result is that you've lost a tiny, tiny bit of fat from every part of your body when you burned at one place.
So with other words you want to follow the tips people sugested above; do cardio because it takes a lot of energy(relative to other exercisces), because when the fat in your legs is burned off, it is continuously re-supplied with fat from all-around, and as you got for a couple of weeks or months you will get a bit smaller everywhere.
Disclaimer:
This is not how it works scientifically, but it usually provides a useful picture for the person who's losing the weight to understand the process.
All I can tell you is, that when a friend of mine was on a type of medication that caused her to lose a lot of weight rapidly, her face was like a deflated balloon...very saggy. In time, her body compensated for the rapid weight loss and she looks wonderful now.
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