52. *blech*
That can be a nasty route even on the best days.
Keep going on I-40 and hop onto 421 westbound. Might want to take a good look on mapquest or google maps. That can be a snarly area. 421 is four lanes (speed limit is 60 or 65?), very easy once past W-S, and will take you right to I-77. Or, you can get off 421 at Yadkinville and take 601 to 74 to I-77. 601 is two lanes and scenic.
OR, you can continue on 421 to the Blue Ridge Parkway and go south from there, as excellently suggested.
I-77 to I-81 is OK, but doesn't really add much fun to the trip. You have the 7 or 8 mile stretch going north on I-77 from NC into VA that can be treacherous if the wind is blowing high (there are warnings to that effect) and then a lot of truck traffic on I-81 going south.
The Blue Ridge Parkway route from Boone south is the best (IMO). You begin to see some dramatic scenery heading through that part. Just remember that the speed limit is 45 (35 around the Moses Cone and Linville areas)