Interstate 15 runs along the east side of Helena, northward toward Great Falls and southward toward Butte. It intersects with U.S. Highways 12/287 that run east and west and extend toward East Helena. Helena Airport is located 2.5 miles from the center of the city. SkyWest, Comair, Horizon, Northwest, and Big Sky Airlines provide 14 daily flights to the city. Bus service is provided by Rimrock Trailways, which connects with Greyhound.
The major north-south routes are U.S. 12, which is known as Montana Avenue, and North Last Chance Gulch, also known as Main Street. Neill Avenue, 6th, 9th and Lyndale are major east-west streets. Transportation is provided by door-to-door bus service and a city taxi service.