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I just made the drive yesterday, half of it being in TS Debby. Good thing I opted for I-75, as parts of I-10, 301, and numerous surface streets were closed due to flooding!
Timing is everything; I leave the Tampa area around 4 AM, and skirt Atlanta via I-675 and I-285, getting through there just before noon. Lots of traffic, but manageable. Heading south, I go the other way, via 26/95, unless I can be on the road by about 3 AM. Atlanta is no place to be @ 6:30 AM!