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By increasing odor detection, cannabinoid type-1 (CB1) receptors in the olfactory bulb help mediate feeding behavior in fasted mice, according to a study published in Nature Neuroscience today (February 9). Researchers from the French Institute of Health and Medical Research (INSERM) and elsewhere have uncovered CB1 receptor-dependent mechanisms through which endocannabinoids and exogenous cannabinoids like THC, the active ingredient in marijuana, increase olfaction and subsequent fasting-induced food intake, and suggest that their work points to potential therapeutic targets for feeding behavior-related human diseases like anorexia and obesity.