Interstate 10, which is a direct route to Phoenix, Los Angeles, Houston, and Dallas, and Interstate 25, which is the direct route to Albuquerque and Denver, traverse the city's south end. U.S. Highway 70 presents a direct route to Interstate Highway 40 at Amarillo. The Las Cruces International Airport, eight miles west of the city, offers commercial service to Albuquerque by Mesa Airlines, and more recently to various cities in the Southwest by Westward Airways. Negotiations are ongoing for increased commercial air service out of Las Cruces, but more air travel takes place at the El Paso International Airport in Texas, about 52 miles to the south of Las Cruces. American, Continental, America West, Delta, United, Frontier, AeroLitoral, and Southwest airlines fly to over 70 cities from El Paso.
Bus and shuttle service is offered by Greyhound-Trailways, Enchanted Southwest Tours, and the Las Cruces Shuttle Service.
Local bus service is offered by Roadrunner Transit, and taxis are available from the Checker/Yellow Cab Company.