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And well surprise, the findings are completely different than that article summarized. In fact vigorous physical activity was a better predicator of longevity than moderate physical activity which was better than being sedentary. No mention of "aging" at all, in fact how would you measure it? Wrinkles?
The article stated that the most physically active people averaged about 1.8 years of extra aging on their biological body clocks. No further explanation was given, so I gave no idea how the researchers measured 'biological aging'
The article stated that the most physically active people averaged about 1.8 years of extra aging on their biological body clocks. No further explanation was given, so I gave no idea how the researchers measured 'biological aging'
From the study:
Quote:
Biological ageing was assessed using blood-based epigenetic ageing measures, namely, principal component (PC)–based DNAm GrimAge[16,17] and DunedinPACE[15]. The measurement and preprocessing of the DNAm levels, as well as additional information on the epigenetic ageing measures, are provided in the online supplementary material. To summarise, DNAm GrimAge is a mortality predictor by design, and it is composite of age, sex, DNAm-based surrogates for seven plasma proteins and smoking pack-years[17]. Recently, PC-based epigenetic clocks have been developed to bolster the reliability and validity of the clocks[16]. We produced PC-based GrimAge estimates using an R package ([16], https://github.com/MorganLevineLab/PC-Clocks). Age acceleration (AAPC-Grim) in years was determined as a residual by regressing the estimated epigenetic age on chronological age. In addition, we obtained PC-based components of GrimAge (adjusted for age), including DNAm smoking pack-years, DNAm adrenomedullin (ADM), DNAm beta-2-microglobulin (B2M), DNAm cystatin C, DNAm growth differentiation factor 15 (GDF15), DNAm leptin, DNAm plasminogen activator inhibitor 1 (PAI-1), and DNAm tissue inhibitor metalloproteinases 1 (TIMP-1).
Basically, surrogate markers, and modeling. Nothing I'd take too seriously. But I want to keep repeating this:
Quote:
Leisure-time physical activity (LTPA) LTPA was measured in metabolic equivalent (MET) hours per day (h/day) using a structured validated questionnaire in 1975, 1981 and 1990[7,19-21] (see online supplementary material and Tables S1-S2 for details).
In other words, people were put into physical activity buckets based on a questionnaire in 1975, 1981, and 1990. No one knows their actual physical activity on a day in day basis.
Imagine if I asked your physical activity for those years, would your physical activity stay constant in that time frame?
Basically, surrogate markers, and modeling. Nothing I'd take too seriously. But I want to keep repeating this:
In other words, people were put into physical activity buckets based on a questionnaire in 1975, 1981, and 1990. No one knows their actual physical activity on a day in day basis.
Imagine if I asked your physical activity for those years, would your physical activity stay constant in that time frame?
The epigenetic stuff interests me but I'd have to invest some serious time reading up on the methodology; as a layperson I am nowhere near qualified to judge the validity of that component of the research. As for the questionnaires, aside from the issue you mentioned, why were the last ones administered in 1990? That's 30+ years unaccounted for....
During strenuous bouts of cardiovascular activity, your body is forced to find alternate ways of getting oxygen to the heart. As a result, you increase the number of blood vessels. This is one of the many reasons cardiovascular exercise leads to lower BP. But also, during a heart attack, increases your odds of survival, as now you have more routes for blood to flow in case one gets blocked.
The many benefits of exercise.
Alex Hutchinson's book 'Endure', which I read within the past year, includes some great discussion of VO2 max, including reflections on nature vs nurture issues related to natural endowment and capacity for improvement
Didnt read the article yet, but I will say I can understand the POSSIBLE PREMISE of the article. There is different types of exercising, extensive RUNNING can be bad on the joints such as your knees, and too much running probably puts wear and tear on the heart.
As was pointed out (and there's plenty of evidence to support it), weight bearing exercises are very important for older adults to help with bone density issues. Balance exercises are also important. And they should find time in their "busy lives" to incorporate them and make it a priority. They may not have a life at all if the have a trip and fall and break a hip. Most people can spare 4% of their day to do these things.
Thank you for posting this. I was shocked that my bone density was poor, no symptoms, so I'm glad you made this comment to encourage other older adults to work on balance and weights. I've learned that breaking a hip has a huge fatality rate. That same point was emphasized by Dr. Attia in his book Outlive when he talked about how any injury can impact an older person's longevity. They quit exercising while recovering and that affects their whole body. He has some great info and tips in that book.
I would say this is a case by case scenario. Fitness is always good imho
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