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Both (which is scary). There's something about the fundamental pathophysiology of hypertension that COVID-19 likes (perhaps constitutionally increased levels of angiotensin-convertng enzyme 2, or some other derangement of the angiotensin-renin system, which may or may not be altered by the medications a patient is taking to treat their hypertension).
We just don't know enough yet to tease much in the way of answers out of the limited data we have. This paper offers a not-too-difficult review of what we know to date. Right now, we can't say much more than that hypertension (whether treated or untreated) is a risk factor.
Does the medical community know of any other virus/disease/pathogen that seems to like hypertension in the same way?
Btw, I don’t doubt what you are saying at all....it just is very curious that this would be the case.
One thing I was glad to see on C-D is a moderator of one forum posted for no more posts on the coronavirus. I used to like to get on the computer to get away from whatever's going on. But now, no matter what the forum is, it's all that's talked about. Yes, I know it's a serious deal. But it doesn't have to be every other word you type.
I'm not paranoid like a lot of these people. I get out and go to the store and I've gone fishing on a couple big lakes within 30 miles. Our governor says to get fresh air but don't congregate. Fishermen never stand within 6 feet of each other. As far as that goes, I can't even get the fish withing 6 feet of my hook! But I see no need to be paranoid. Just be careful and watch what you do and where you go.
You can’t get away from everybody panicking, even in the garden forum. One reason why I go there is for relaxation in the first place. I think we should have a limit on how many CV thread we can have per forum. If you are crazy enough and want more information go there. I only get a snap shot of new cases everyday in my area just to see if the curve is flattening. No more news period.
Does the medical community know of any other virus/disease/pathogen that seems to like hypertension in the same way?
Btw, I don’t doubt what you are saying at all....it just is very curious that this would be the case.
I'm not aware of any other infectious diseases which specifically like hypertension, but I'm not an expert. But any virus has to find its way into a cell before it can begin its hostile takeover of the cellular machinery, which usually means it has to bind to a glycoprotein on the cell's surface as part of the entry process. So anything that alters either the expression or structure of whatever glycoprotein is key to that virus's entry can affect the virus's ability to get in. Perhaps the best-known example is the delta-32 mutation of the CCR5 protein, which confers resistance to AIDS, but which may also increase the risk of developing a serious case of West Nile Virus.
I'm not aware of any other infectious diseases which specifically like hypertension, but I'm not an expert. But any virus has to find its way into a cell before it can begin its hostile takeover of the cellular machinery, which usually means it has to bind to a glycoprotein on the cell's surface as part of the entry process. So anything that alters either the expression or structure of whatever glycoprotein is key to that virus's entry can affect the virus's ability to get in. Perhaps the best-known example is the delta-32 mutation of the CCR5 protein, which confers resistance to AIDS, but which may also increase the risk of developing a serious case of West Nile Virus.
Thanks for sharing your knowledge Aredhel. It is appreciated.
After reading that article, I am reminded of why I dropped out of organic chemistry.
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Originally Posted by Cabound1
Does the medical community know of any other virus/disease/pathogen that seems to like hypertension in the same way?
Btw, I don’t doubt what you are saying at all....it just is very curious that this would be the case.
It is not that the disease 'likes' hypertension, it does not.
The heart/circulatory system works in conjunction with the lungs to supply oxygen throughout the body. This disease affects the lungs, inhibiting the lungs' ability to present oxygen to the cardiovascular system. Failing to obtain enough oxygen from the lungs, the cardiovascular system works harder in an attempt to obtain more oxygen from the lungs...an attempt which is futile, because the lungs cannot present sufficient oxygen to the cardiovascular system.
Unfortunately, the cardiovascular system is not 'intelligent', and cannot discern the fact that the lungs are unable to present sufficient oxygen. Therefore, the cardiovascular system works harder in order to attempt to obtain the oxygen that is needed, despite the fact that it is unavailable. Blood pressure increases. In an otherwise healthy person, this increase may be tolerable for some period of time...but for others...
Im pretty sure younger people and kids are going to suffer quite and bit in an extended tanked economy. And some will die as a result.
But you are welcome to have them all come and live with you and take care of them vs. asking the broke govt to do more.
I'm not sure what the solution is, but the more we know, the more the true mortality rate of total infected people (symptomatic and asymptomatic) seems to decline. While the news will always highlight the "otherwise healthy young person who dies," statistically - someone under 50 is pretty unlikely to die from this. Even among those who are 80+, and most at that age will have comorbidities, the survival rate is around 80% worldwide.
I'm OK for now. Many of my friends and social circle are already out of work. Locally, we're looking at many thousands of job losses in an area that didn't have much going for it to begin with.
Virtually all of my bar/restaurant friends are out of work. The establishment owners may or may not reopen. The better capitalized ones probably will, but who knows when that will be. Most of my retail friends that aren't in the essential businesses like Walmart or grocery stores are also out of work.
It's cascading beyond that now. The banks are laying off because of social distancing rules/closing branches, and because there is so little underlying activity. My ex was laid off from a regional bank last Friday. The bank my mom retired from last year is laying off as well.
What's this going to do to "in person" industries like auto or real estate sales? Is anyone really thinking of a big ticket purchase now? Those people are at risk.
My ex was laid off from a regional bank last Friday. The bank my mom retired from last year is laying off as well.
If your ex was laid off, she can apply for unemployment compensation and the recent bill passed by Congress allowed for those laid off to have full salary replacement plus an extra $600 per week.
March 6th someone came in with the flu (thought it was the flu). They sent her home right away.
The whole office got it. 7 diagnosed with the virus. Tested last week. Got results yesterday.
Three more have it now after being tested once (came back negative); went for another test (positive).
All have self quarantined. None of them have gone to the hospital except the realtor friend.
What she told me was shocking. You are better to recover at home. It was a private hospital also and she tested negative first test; second test not back but first doctor told her to leave there; that she would get sicker. She did have an underlying health condition but went home and is now doing so much better.
After the first positive test, they get tested 14 days later and they need 2 negative tests in order to be marked OK.
Ages: 40's, 50's, early 60's (3 attorneys also got it)
All from Miami. All are recovering and doing better.
It is not that the disease 'likes' hypertension, it does not.
The heart/circulatory system works in conjunction with the lungs to supply oxygen throughout the body. This disease affects the lungs, inhibiting the lungs' ability to present oxygen to the cardiovascular system. Failing to obtain enough oxygen from the lungs, the cardiovascular system works harder in an attempt to obtain more oxygen from the lungs...an attempt which is futile, because the lungs cannot present sufficient oxygen to the cardiovascular system.
Unfortunately, the cardiovascular system is not 'intelligent', and cannot discern the fact that the lungs are unable to present sufficient oxygen. Therefore, the cardiovascular system works harder in order to attempt to obtain the oxygen that is needed, despite the fact that it is unavailable. Blood pressure increases. In an otherwise healthy person, this increase may be tolerable for some period of time...but for others...
It’s a bit more complicated than that, Zymer. Check out the paper I linked to in post 39. Some of the physiologic changes associated with hypertension may actually aid the virus in infecting cells.
Yeah, I guess you are right. The best thing to do is to line up everyone over 70 and do them in.
There are people that are not old that are dying from this.
..the national socialist democrats of yesteryear would agree with you.
(yes i know you were being sarcastic)
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Told to me by a realtor friend
