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San Diego. I'd be less likely to have my livelihood ruined over my political views there than I would in San Francisco.
Kirksville, MO or Christiansburg, VA?
Christiansburg, VA
Close decision. Slight edge of small town VA over small town MO IMO. Can explore East Coast region/DC area/Blue Ridge Mtns & South region from there. Kirksville is not close enough to MN & WI people I know for it to be a factor.
Scottsdale because I prefer the Phoenix Metro Area to the Las Vegas Metro Area.
Medford, OR vs Redding, CA
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