You'd have to start by asking yourself what your needs are and what budget you have. But the general fact is that the closer to downtown you get, the higher the price per square foot. Schools' desirability will also affect the price per square foot. Although, there are definitely highly priced neighborhoods with schools that are not the highly demanded ones (e.g. Hartland, Ellerslie at Delong, etc.). But, those later neighborhoods are atypical (larger lots, all brick, brand new high-end construction, etc). If you're a parent, obviously schools are important to you. Check out this site as it will give you a report card to each Kentucky School (Lexington is in Fayette County):
School Report Card Archives. The last page of each report card lists all the school's awards/achievements/extra curriculum offerings, etc
Also, FCPS.net is the Fayette County Public School website and you can see details of each school. It's important to go go visit a school as scores can only tell you so much. To me, the environment is worth more than the average grades of the student population! There are great schools that appear worse than others because they have a higher percentage of learning disabled and/or economically disadvantaged kids. Yet if your toured it you'd see that there is more respect for each other, the teachers, and their environment than in some of the other "better" schools. ....Just trying to give you more options, here, really