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The .22 magnum is not a negligible caliber, even from a 2" barrel, but a sub-micro revolver is really only a good defensive firearm when the alternative is no firearm at all.
Single action .22 magnum revolver for self-defense? Yikes!! It looks like a toy and would not look very intimidating to a bad guy -- especially one high or drunk. Your best bet would be to palm it, and deploy it against the armpit toward the torso or at the temple of the bad guy before he realizes how under-armed you are. As hard as it would be to pull back the hammer (can't use re-c-o-c-k on this forum) after every shot . . . I would try to empty all rounds into the head/neck area. It's your only chance at surviving a violent encounter.
Personally, you'd probably be better off with a decent folding fighting knife. That gun is best suited to intimidation or assassination.
I have other pistols, obviously. Thanks for the laughs, especially, about the game, CLUE. Hahaha
LOL, but from your post having other handguns wasn't obvious.
I think the smallest I'd go is the Ruger SR9C for the front pocket, but that's would just buy me time to get to the .45 in case there was a possible hangup getting to the .45.
Otherwise I'll stick with just the .45.
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