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Developing a new prescription medicine that gains marketing approval is estimated to cost drugmakers $2.6 billion according to a recent study by Tufts Center for the Study of Drug Development and published in the Journal of Health Economics. This is up from $802 million in 2003—equal to approximately $1 billion in 2013 dollars, and thus a 145 percent increase in the ten year study gap. Furthermore, while the average time it takes to bring a drug through clinical trials has decreased, the rate of success has gone down by almost half, to just 12 percent.
same article - close to 90% of drugs will fail in development before ever getting to the point of being sold
Quote:
“Based on an analysis of 1,442 experimental drugs that were in clinical tests in recent years through the end of 2013, DiMasi said the overall chance that a drug entering clinical development will be approved for marketing is just under 12 percent.”
“Approximately seven out of eight compounds that enter the clinical testing pipeline will fail in development,” DiMasi said. “Put another way, you need to put an average of 8.5 compounds in clinical development to get one approval.”
Seiffert notes that DiMasi arrived at the 12 percent figure using a “weighted average, since as of the study, just 7 percent of the 1,442 drugs had actually been approved. Fully 80 percent had been abandoned by the companies developing them, and the other 13 percent were still in active development. DiMasi said it’s likely that many of the drugs in later development will eventually earn approval, hence the overall 12 percent rate.”
Drug to Treat Rare Disease Costs Millions
Pricing Creates a Crisis
Dawn Patterson keeps a multimillion-dollar drug in the fridge, next to a bottle of root beer and a jar of salsa.
“My jaw really did drop,” Ms. Patterson said. “I was like, what? This is crazy
It was long called "Orphan Diseases" few get them and fewer can afford treatment. However, if govt had its way, this family would find they might not get it.
I'm glad the union paid and glad they spoke with the pharmaceutical company and got the cost down. But how horrible to be in that situation. Relief is a fridge away and $6 million also...
So headline was semi-misleading—
6/3=2 million per person...
1–does a pharmaceutical company HAVE to reduce the price once it’s made back its research costs? I don’t think so...because how does anyone really know what those research costs were? There are no itemized expenditures that insurance companies get access to showing the ROI for any particular drug...
2–if there are any Medicare or Medicaid users likely the government covers full cost PLUS what the company is losing to negotiated reductions to private insurance companies like the Boilermakers’ Union...
And yes I understand that new medications can be very expensive
But what did the wife do BEFORE this med came along?
And WHEN did she know she has a rare, incureable, expensive disease?
Before or after having children?
And then there is the “new” treatment for sepsis—the generalized blood poisoning that comes when the body’s immune system can’t fight infection...
Vitamin C and steroids IV in large doses—
Read article about ER doctor that tried new treatment on patient that was so close to dying it was a forlorn hope of a cure—
But it worked...
Tried it on several other critical, near death patients with positive results
Wrote a paper about it
Other ER doctors in his hospital system tried it w/positive results
The issue??
Getting it approved as “standard practice” and the fact that drug companies won’t want to deal with it because the ingredients are too cheap/no copy=write...
And then there is the “new” treatment for sepsis—the generalized blood poisoning that comes when the body’s immune system can’t fight infection...
Vitamin C and steroids IV in large doses—
Read article about ER doctor that tried new treatment on patient that was so close to dying it was a forlorn hope of a cure—
But it worked...
Tried it on several other critical, near death patients with positive results
Wrote a paper about it
Other ER doctors in his hospital system tried it w/positive results
The issue??
Getting it approved as “standard practice” and the fact that drug companies won’t want to deal with it because the ingredients are too cheap/no copy=write...
There are multiple studies that have taken or are taking place on this. That's standard for a new treatment. There are multiple funding sources including foundations, the NIH, and academic medical centers which conduct all kinds of research.
They are giving it to me for $25 a month, because my insurance wanted me to try other medications first, and my doctor knew they wouldn't work.
If they stop the program I'll have to play the game with my insurance.
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It's a fact. If you want to research it, go ahead. I'm not your secretary. Otherwise stay ignorant.
As always, completely stunned by the lack of effort put forth by those who claim to be "knowledgable." It's almost like they don't want to know what they don't know. Eliminates accountability.
There are 0-ZERO-drugs to treat my disease. It is RARE. The disease in the article is RARE. There are no choices in treatment. Most of the time there is no treatment. So yeah cite your sources.
There are 0-ZERO-drugs to treat my disease. It is RARE. The disease in the article is RARE. There are no choices in treatment. Most of the time there is no treatment. So yeah cite your sources.
Right.
And my statement was about the fact that the industry continues to produce me-too drugs. A slight variation on something that already exists. For the only sake of profitability.
Which means YOUR rare disease? Not profitable. They'll never make a drug. They'll never bother with it, no money in it.
You are actually AGREEING with me. Shocking, I know.
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