I walked from the South Ferry to 125th/St. Nick (mostly via the West Side Path) last year.
Most recently, I've walked from near Penn Station to Boro Hall in Brooklyn.
Sometimes on my lunch hour, I go from my office at 28th and 7th and walk to Franklin/Varick or to 72nd/Broadway - both of which take 45 minutes.
What can I say? I like taking long walks.