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So far, GLP1-Receptor agonists have been approved for treating diabetes and obesity. There will likely be approvals for additional indications for drugs in this class coming in the years ahead. The following figures are taken from: "Glucagon-like peptide 1 receptor agonists: cardiovascular benefits and mechanisms of action", Nature Reviews Cardiology, March 2023. https://www.nature.com/articles/s41569-023-00849-3
The short vertical arrows pointing down indicate a process that is downregulated, and the ones pointing up indicate a process that is upregulated. HFpEF is heart failure with preserved ejection fraction, and HFrEF is heart failure with reduced ejection fraction. If it's not apparent - this bodes well for GLP1-Receptor agonists.
Last edited by OutdoorLover; 11-29-2023 at 03:57 PM..
I stand by what I said. Here for example, consider the first line of the abstract from this research article entitled
Title: "Protein intake and lean body mass preservation during energy intake restriction in overweight older adults"...
Now, many studies have shown that this lean body mass loss can be mitigated by increasing protein intake and performing exercise during the caloric restriction.
During dramatic losses of weight, especially rapid losses of weight, some muscle mass loss is normal. But for 50% of your weight loss to be muscle is not normal. That's really setting you up for failure.
During dramatic losses of weight, especially rapid losses of weight, some muscle mass loss is normal. But for 50% of your weight loss to be muscle is not normal. That's really setting you up for failure.
I think that the sharp distinction that you're drawing between weight loss induced by GLP1-Receptor agonists versus dieting and bariatric surgery, is incorrect.
I think that the sharp distinction that you're drawing between weight loss induced by GLP1-Receptor agonists versus dieting and bariatric surgery, is incorrect.
A systematic review of the literature shows that muscle loss is roughly 25% of weight loss during a weight loss program initiated through lifestyle changes (diet + exercise). : https://onlinelibrary.wiley.com/doi/10.1111/obr.12143
So, taking Ozempic, you're essentially doubling the muscle loss you would have seen if you achieved that same weight loss through diet.
And of course, this doesn't take into account the type of diet and starting point. People who are obese (the same people used in Ozempic's trials) would only see 10% of their total weight loss be muscle mass, whereas people who are normal weight or near normal would see 35%.
A systematic review of the literature shows that muscle loss is roughly 25% of weight loss during a weight loss program initiated through lifestyle changes (diet + exercise). : https://onlinelibrary.wiley.com/doi/10.1111/obr.12143
So, taking Ozempic, you're essentially doubling the muscle loss you would have seen if you achieved that same weight loss through diet.
And of course, this doesn't take into account the type of diet and starting point. People who are obese (the same people used in Ozempic's trials) would only see 10% of their total weight loss be muscle mass, whereas people who are normal weight or near normal would see 35%.
I have yet to see a trial of Wegovy that showed 50% or greater proportion of weight lost as lean muscle mass. Can you produce these trial results?
"Endocrinologists and obesity medicine specialists said that while muscle mass loss can be a side effect of semaglutide, it is not unique to the drug or the GLP-1 agonist drug class.
'Muscle mass loss is part-and-parcel to losing weight,' said Amy Rothberg of the University of Michigan, who is also a spokesperson for the Endocrine Society. 'So in the context that semaglutide helps people lose weight, they are going to lose muscle mass.'
'But you lose muscle mass irrespective of the modality, whether that's diet and exercise, bariatric surgery, or medications,' she said."
"According to Rothberg, people generally lose fat mass to lean mass at a ratio of 2:1. While this varies by age, gender, and physical conditioning, Rothberg noted that the STEP 1 data appear to fall within those parameters."
Here's another interesting data point: a large international clinical trial that followed 17,000 patients on Semaglutide (or placebo) injections for 3 years, found that there was a 20% reduction in cardiac events - namely heart attack and stroke, for those receiving the medication. This trial, dubbed SELECT, just reported results this month.
The research article in the New England Journal of Medicine - when they say that the hazard ratio between the placebo group and the Semaglutide group was 0.80 for primary cardiovascular end-point events - that's the 20% reduction in heart attacks and strokes. https://www.nejm.org/doi/10.1056/NEJMoa2307563
The average participant lost 10kgs of fat and 7kgs of muscle. Of course, this is the average. Many were worse off.
These numbers are unprecedented btw. If they were in line with normal expectations, it would be 10kgs of fat and 3kgs of muscle, and I would not be talking about it.
Last edited by WaikikiWaves; 11-29-2023 at 08:54 PM..
My doctor recommended Ozempic for me, I didn't ask. Clearly she understands losing the 45 pounds is a struggle for me and I need help.
Quote:
Originally Posted by allthatglitters
Thank you. Yes, my doctor sent me to a dietician who recommended a plant-based diet for me.
That was back in June.
I'm now nearing my ideal weight, just a couple more pounds to shed. I'm on a healthy diet and I've learned portion control. I've decided to stop taking Ozempic. Hopefully I will be able to maintain and not gain it back.
I had no side effects, the reason for stopping the drug is because of the cost. Both my health insurance companies denied my claim, and will not cover it. I simply no longer desire to pay for such an expensive weight loss tool on a monthly basis.
I got this.
ETA : The reason my insurance won't cover it is because I'm healthy...I had no serious health complications when I was overweight.
Last edited by allthatglitters; 12-16-2023 at 01:38 PM..
I'm now nearing my ideal weight, just a couple more pounds to shed. I'm on a healthy diet and I've learned portion control. I've decided to stop taking Ozempic. Hopefully I will be able to maintain and not gain it back.
I had no side effects, the reason for stopping the drug is because of the cost. Both my health insurance companies denied my claim, and will not cover it. I simply no longer desire to pay for such an expensive weight loss tool on a monthly basis.
I got this.
ETA : The reason my insurance won't cover it is because I'm healthy...I had no serious health complications when I was overweight.
Thanks for sharing. So how did the Ozempic work for you? Did you not have an appetite? Did you change what you ate and drank? Or did the med burn more calories?
Let us know how you do once you're finished with the meds. I haven't really heard much about how anyone has done once they quit.
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