Quote:
Originally Posted by Oklazona Bound
Simply posting endless links from others who claim the vaccine is dangerous or so called data from dubious sources.
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The below is a good example of disinformation.
Quote:
Originally Posted by Sprawling_Homeowner
Dubious sources - you mean like the FDA and now the NIH?
Informed consent disclosure to vaccine trial subjects of risk of COVID-19 vaccines worsening clinical disease
Results of the study: COVID-19 vaccines designed to elicit neutralising antibodies may sensitise vaccine recipients to more severe disease than if they were not vaccinated. Vaccines for SARS, MERS and RSV have never been approved, and the data generated in the development and testing of these vaccines suggest a serious mechanistic concern: that vaccines designed empirically using the traditional approach (consisting of the unmodified or minimally modified coronavirus viral spike to elicit neutralising antibodies), be they composed of protein, viral vector, DNA or RNA and irrespective of delivery method, may worsen COVID-19 disease via antibody-dependent enhancement (ADE). This risk is sufficiently obscured in clinical trial protocols and consent forms for ongoing COVID-19 vaccine trials that adequate patient comprehension of this risk is unlikely to occur, obviating truly informed consent by subjects in these trials. |
Yes, "dubious sources." The FDA and NIH did
not say that. The review is of other vaccines (for example, dengue fever and an early attempt at SARS vaccine using a different technology years ago) that was issued "open access" (pay for online availability)
in October 2020. There's no connection to NIH except that the National Library of Medicine at NIH is the world's largest online
compiler of biomedical literature. No link to the FDA except, I suppose, they would be the ones to issue the authors' proposed disclaimer.
The authors note: "Current data on COVID‐19 vaccines is limited, but
does not so far reveal evidence of ADE of disease." Still they call for a disclaimer stating that there IS a risk: "The specific and significant COVID-19 risk of ADE
should have been and should be prominently and independently disclosed to research subjects currently in vaccine trials, as well as those being recruited for the trials and future patients after vaccine approval, in order to meet the medical ethics standard of patient comprehension for informed consent.
https://onlinelibrary.wiley.com/doi/10.1111/ijcp.13795
This is what a pharmaceutical drug researcher had to say on the topic in
June 2020.
"Past efficacy and on to adverse effects, one thing that has been extensively talked about is antibody-dependent enhancement (ADE), because this has been seen in other vaccine candidates (
such as for dengue, where the reasons don’t really apply here) but also in attempts to develop vaccines against the closely-related SARS coronavirus. To be honest, I am getting less and less worried about that as time goes on. The various mAb and vaccine teams have been alert for signs of ADE all along the way, and so far we appear to be in the clear. This doesn’t mean that we can forget about the issue, but it’s not at the top of the worry list, either."
https://blogs.sciencemag.org/pipelin...might-go-wrong
Here's a recent analysis analysis of covid vaccines and ADE dated
March 2021. Interesting enough, it turns out that avoiding ADE was yet one more reason to target the spike protein. Turns out ADE is more of a potential problem when using inactive whole-virus vaccines, the so-called traditional vaccines.
https://www.medpagetoday.com/special...clusives/91648
Since then there have been re-infections of those who have been vaccinated, with no still no sign of ADE. Is it too soon? This back in March in the MedPage article:
"Furthermore, ADE is an acute problem, and it can be very dramatic.
If it was an issue with these vaccines, we would have spotted it by now, said Brian Lichty, PhD, an associate professor in pathology and molecular medicine at McMaster University in Toronto. "It'll kill you quickly. In all the places I'm aware of ADE happening, it is an acute, mostly cytokine-driven event," he told MedPage Today."
https://www.medpagetoday.com/special...clusives/91648
Except once again for the frail or elderly, post-vaccination illness appears to be quite mild - to a much greater extent than covid itself.
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