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Old 04-23-2020, 03:09 PM
 
Location: SLC
3,102 posts, read 2,224,306 times
Reputation: 9061

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Quote:
Originally Posted by Aredhel View Post
Tests don't have a fixed false positive or false negative rate. Those depend on the sensitivity and specificity of the test and the prevalence of what you're testing for in the population you are testing. What is fixed is a test's sensitivity and specificity. Running exactly the same test in two populations with a very different incidence of whatever it is you are testing for can give very different false positive and false negative rates.
https://en.wikipedia.org/wiki/Positi...dictive_values

The Abbot test currently has a claimed sensitivity of 100% and specificity of 99.5% (https://www.evaluate.com/vantage/art...ecific-problem). I expect both numbers to go down slightly as most data comes in, as these tests haven't been as thoroughly researched as most new tests are before being brought to market. (In particular, no test is ever 100% sensitive or specific, though greater than 99.5 percent is what most good tests aim for - the higher, the better.)
One should be able to determine the False Positive and False Negative rates from specificity and sensitivity numbers.

True Negative = TN
True Positive = TP
False Negative = FN
False Negative = FP

Specificity = SP
Sensitivity = ST

SP = 100 * TN / (TN + FP)

ST = 100 * TP / (TP + FN)

TN + TP + FN + FP = Testing sample size

If SP, SN and Testing Sample Size are known, then we have 3 equations and 4 unknowns. I am missing one equation here to get to the TN, TP, FN, FP numbers. I am sure they have it for calculating the SP and ST. Hopefully someone can spot what I am missing...
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Old 04-23-2020, 03:15 PM
 
14,221 posts, read 6,963,795 times
Reputation: 6059
Quote:
Originally Posted by rjshae View Post
People in NY probably have better access to health care than most. Like you, I'm skeptical that they could be more healthy though. They could well have a higher preponderance of people with existing medical conditions, since they are more likely to be rescued from death.
NY has significantly lower obesity rates.

I dont think people in West Virginia would have the same death rate as people in NY from this virus.
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Old 04-23-2020, 03:23 PM
 
Location: Omaha, Nebraska
10,363 posts, read 7,990,783 times
Reputation: 27773
Quote:
Originally Posted by kavm View Post
One should be able to determine the False Positive and False Negative rates from specificity and sensitivity numbers.
No, they vary with the prevalence of the condition in the population. You have to do a Bayesian analysis to calculate the false positive and false negative rates for a population for which the analyte you're testing for is present at X% of the population. Look at the Wikipedia link I posted (here) to see the actual calculations and some worked examples (using the fecal occult blood test as a screening tool for colon cancer).
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Old 04-23-2020, 03:26 PM
 
Location: Foot of the Rockies
90,297 posts, read 120,796,716 times
Reputation: 35920
Quote:
Originally Posted by parentologist View Post
Bad news. Accidentally-released preliminary info from WHO on remdesivir in China, showed no benefit.

https://www.statnews.com/2020/04/23/...irus-patients/
Well, what a surprise! /s Discouraging though.

Last edited by Katarina Witt; 04-23-2020 at 03:43 PM..
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Old 04-23-2020, 04:00 PM
 
17,587 posts, read 13,367,588 times
Reputation: 33035
Default NIH Panel Develops COVID-19 Treatment Guidelines

https://www.drugtopics.com/coronavir...4-E2A3E6E190FE

https://covid19treatmentguidelines.n.../introduction/

Quote:
These Treatment Guidelines have been developed to inform clinicians how to care for patients with COVID-19. Because clinical information about the optimal management of COVID-19 is evolving quickly, these Guidelines will be updated frequently as published data and other authoritative information becomes available.
At least, things are starting to move!
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Old 04-23-2020, 04:13 PM
 
6,345 posts, read 8,122,671 times
Reputation: 8784
Quote:
Originally Posted by parentologist View Post
Bad news. Accidentally-released preliminary info from WHO on remdesivir in China, showed no benefit.

https://www.statnews.com/2020/04/23/...irus-patients/
If there was only a way to bet against these companies long-term. The majority of drug trials flame out. I would end up losing my shirt, if they stocks keep rising short term.
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Old 04-23-2020, 05:29 PM
 
Location: SLC
3,102 posts, read 2,224,306 times
Reputation: 9061
Quote:
Originally Posted by kavm View Post
A very interesting idea -the therapeutic application of molecular hydrogen gas. This adaptive anti-oxidant has great potential in reducing/controlling hyperinflammation. It is produced by a molecular hydrogen gas generator and can be administered via a nasal cunnula. Inexpensive, non-invasive and with high safety profile.


https://youtu.be/-oh9Ztgjm4A

I am not a doctor but seemed very compelling to me.
This got lost in the other emerging headlines. Would like to reiterate that it seemed fairly hopeful. I saw that there is one trial on this idea...
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Old 04-23-2020, 07:24 PM
 
Location: New Jersey
4,182 posts, read 5,064,936 times
Reputation: 4233
Quote:
Originally Posted by PCALMike View Post
NY has significantly lower obesity rates.

Got a cite for that statement ?
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Old 04-23-2020, 07:50 PM
 
Location: Georgia, USA
37,110 posts, read 41,284,508 times
Reputation: 45170
Quote:
Originally Posted by PCALMike View Post
NY has significantly lower obesity rates.

I dont think people in West Virginia would have the same death rate as people in NY from this virus.
https://www1.nyc.gov/site/doh/health...s/obesity.page

https://www.health.ny.gov/prevention/obesity/

WV: 981 cases, 31 deaths.

Last edited by suzy_q2010; 04-23-2020 at 08:01 PM..
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Old 04-23-2020, 08:02 PM
 
Location: New Jersey
4,182 posts, read 5,064,936 times
Reputation: 4233

I live just across the river in NJ, and knew it was bad over there - but not that bad.


(not that NJ is much better)
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