Single most significant event in all human history. (DNA, president, atomic bomb)
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How about the Big Bang? Certainly no human history would have been possible without it.
This is what happens when you don't define the terms. Exactly what the span of time that we are talking about here?
The Big Bang was of course pre human history and thus disqualified.
However, you have correctly identified the problem with threads like this which pose enormously general questions and provide no criteria or definitions to narrow the nominations.
Certainly becoming human is the most significant thing in human history, but that was not an event, it was a process which took place over an immensely long period of time.
...unless of course Arthur C. Clarke got it right in 2001 and it was a monolith generated event which happened almost instantly.
If there is one single event in human history that changed everything about humanity what would it be?
I would say the Resurrection of Christ over two thousand years ago.
Not even close. You do realize that the majority of the world doesn't believe in Christ, don't you. It might be significant to you, but not to the world. If it even happened.
The most significant event in shaping the world as we know it was the invention, by Gutenberg, of the movable press. It took knowledge and education out of the hands of the ruling class (either the church or the aristocracy) and made it available to the common man, allowing him to move up in the world and get out from under their oppression.
What about the guy who used something that resembled a condom? Just think how over-populated we would be now.
Arab nomads pushed stones in the uterus of their camels to prevent conception thousands of years ago. A variety of effective spermicides were described before there were microscopes to suspect the existence of sperm. Hippocrates (400 BC) mentioned intrauterine devices, according to "Human sexuality: an encyclopedia" By Vern L. Bullough.
The discovery of language, changed the world forever.
Something which already exists, but is unknown, may be discovered. Language wasn't discovered, it was developed. So it is more the invention of language which you reference.
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