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You can’t compare the numbers because they use different criteria and mean different things .
As an example Johnson and Johnson is likely the best of the lot ..not only one shot but it performed the best in keeping one out of the hospital and from death ..which is after all the name of the game ..it was trial tested in Africa as one of the locations and included the variants .
It has been the better choice for reducing the seriousness of getting it .
So while on the surface the media made it look the least effective it actually is the best in many opinions.
One of the best sources to learn is zdogg ..he has the greatest minds on the subject on his shows and this has become my one source for learning tha facts
Zdogg's point is to not discount that in the end JnJ "does the job" and he warns against discounting the vaccine - which is completely fair. But then he turns around the does the same thing (overemphasizing one facet of a vaccine with imprecise and incomplete comparisons) ...
Listened to the video ... zdogg left out a fair amount. For example, the mRNA vaccines performed better when it came to hospitalization and death at 1 week and 2 weeks out - 100% prevention. JnJ was at about 80% but - zdoggs point - the JnJ does appear to have good durability and reached that level of protection some weeks later. Still it's not possible to improve over 100%,
The mRNA vaccines trials (Pfizer, at least) were designed to measure - in part - symptomatic covid period, with that accomplished at 95%. JnJ used a different design collapsing mild disease into moderate to severe categories ((I believe) arriving at about 70+ percent post-vaccination in a non-variant population. Because he's only working from a press release, the FDA analysis may provide more data.
He also makes it sound like the JnJ worked best for older adults. JnJ did have a substantial sample size of those over 65. (AZ did not, which is one of its many phase 3 trial weaknesses and why the EU did not approve it for that age group.). Pfizer also showed no reduction in efficacy for the elderly Moderna's declined to about 85%, but that may be an artifact of a somewhat smaller sample size.
zdogg states that only the JnJ (and Novavax) were efficacious against the SA - in part - in clinical trials. That 's technically true but it's only because by chance those vaccines entered Phase 3 trials in locations where the the variants were then circulating - to an unknown degree, unless J&J can give the FDA data.
The mRNA vaccines were tested earlier. Reduced but hopefully still somewhat efficacy is a reasonable projection. The clinical data are now being developed - and because they will be later yet almost certainly accompanied by variant genomic mapping will provide the then best and most precise field estimates.
JnJ is a strong candidate - with absolutely the seemingly lower efficacy far from the only relevant measure. But it's just too early to start declaring winners and losers.
IF JnJ continues to be administered as a one shot, that will be an advantage - particularly in less health-conscious subpopulations or third-world countries. Still two-shot trials are underway; Gottlieb recommends getting access to a second tranche of JnJ for an eventual second shot that might improve total efficacy and be modified to take into account the variants.
In the end, the 'best' vaccine may be the one that proves to be the most durable, and here JnJ is a strong candidate. Another key variable will be which vaccines works best to prevent transmission. The massive Pfizer rollout in Israel collecting data on literally millions under "real-life" conditions are providing new and so far very positive data.
I have been reading that one dose of Moderna vaccine is 80 % effective and that one dose of the Pfizer vaccine is 52 percent effective.
Does this mean that one dose of these vaccines reduces the risk of getting COVID to 20% or 48% respectively, or does that mean if you get infected, the severity of the case is reduced by 80% or 52% ?
I tried to read up on the answer, no luck .
The Pfizer trials indicated 52 percent effectiveness - in the phase 3 trial, not for any one individual - after two weeks until the second shot was due. That would have been for "observable" covid, which is defined as any one covid symptom on the CDC list plus a positive PCR. (It does not include the asymptomatic.).
One week after the Pfizer second shot, measured effectiveness was 95 percent for mild disease (I believe the same % for severe) with no hospitalizations or deaths. Likewise no severe - ICU - deaths for Moderna (two weeks post-second shot).
Extensive data mining underway on the Pfizer data in Israel with an analysis showing that Pfizer efficacy continues to rise post first shot to reach 91% - no end point, since this is a work in progress. This led for some to call for delaying the 2nd Pfizer shot like what's being done in the UK. One of the concerns is durability, since there don't seem to be clinical trials. How long will that apparently 91% seeming protection be maintained without the needed booster?
Yesterday, the CDC, Fauci, WH indicated that the U.S. would not adopt a modified dosage regimen but stick to the two-shot rollout & timing tested in the clinical trials.
I will not get it and are they forcing the children to do it and take vacine in long island?
They’ve been forcing children to get vaccinated for years by holding their education hostage.
And they’ll do the same to everyone else eventually.
They will find a way to force everyone to get it.
Most likely, by putting pressure on employers to have a “vaccination policy”.
AKA you wanna work here you need to have your shots.
They’ve been forcing children to get vaccinated for years by holding their education hostage.
And they’ll do the same to everyone else eventually.
They will find a way to force everyone to get it.
Most likely, by putting pressure on employers to have a “vaccination policy”.
AKA you wanna work here you need to have your shots.
The Pfizer trials indicated 52 percent effectiveness - in the phase 3 trial, not for any one individual - after two weeks until the second shot was due. That would have been for "observable" covid, which is defined as any one covid symptom on the CDC list plus a positive PCR. (It does not include the asymptomatic.).
One week after the Pfizer second shot, measured effectiveness was 95 percent for mild disease (I believe the same % for severe) with no hospitalizations or deaths. Likewise no severe - ICU - deaths for Moderna (two weeks post-second shot).
Extensive data mining underway on the Pfizer data in Israel with an analysis showing that Pfizer efficacy continues to rise post first shot to reach 91% - no end point, since this is a work in progress. This led for some to call for delaying the 2nd Pfizer shot like what's being done in the UK. One of the concerns is durability, since there don't seem to be clinical trials. How long will that apparently 91% seeming protection be maintained without the needed booster?
Yesterday, the CDC, Fauci, WH indicated that the U.S. would not adopt a modified dosage regimen but stick to the two-shot rollout & timing tested in the clinical trials.
thank you and Mathjak for your replies. I had read about the Israel study.. apparently the Pfizer vaccine starts ramping up fourteen days after the first shot (from zero after 14 days to 91% after 21 days).
Good luck with that ....I got a great immune system but that did not stop me from being hospitalized for weeks with covid .
In fact a good immune system can create a lot of damage a lot of times ..most of my respiratory inflammation was the result of my own immune system trying to pound the invader...
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